Haegarda

Haegarda

Generic Name: C1 esterase inhibitor subcutaneous (human)  [ C1 ES-ter-ase-in-HIB-it-or ]
Drug Class: Hereditary angioedema agents

What is Haegarda?

Haegarda is a human-derived protein therapy used in the treatment of Hereditary Angioedema (HAE)—a rare genetic condition that can cause sudden and severe swelling in areas like the face, abdomen, and throat. People with HAE lack a sufficient amount of a natural protein called C1 esterase inhibitor, which helps regulate inflammation and swelling in the body.

Haegarda is administered via subcutaneous injection and is used routinely (twice a week) to prevent HAE attacks in patients aged 6 years and older.

Important: Haegarda is not a rescue treatment for acute HAE attacks. If an emergency swelling episode occurs, seek immediate treatment using the emergency medication provided by your specialist.

Side Effects

Seek immediate help if you experience:

• Hives or swelling around the face and throat
• Chest pain or tightness
• Light-headedness or fainting
• Sudden numbness or weakness on one side
• Vision problems or slurred speech
• Leg pain, redness, or warmth (possible clot)

Common side effects may include:

• Sore throat, nasal congestion
• Headache or dizziness
• Nausea or vomiting
• Rash or itching
• Fever
• Injection site reactions (bruising, swelling, pain, redness)

For any side effects, speak to your doctor or report them through the MHRA Yellow Card Scheme.

Warnings

Do not use Haegarda if you have ever experienced a life-threatening allergic reaction to C1 esterase inhibitor products, including anaphylaxis.

Since Haegarda is made from donated human plasma, there is a very small risk that it could carry infectious agents, even though the plasma is tested and treated. Your healthcare provider can discuss this risk with you in more detail.

Seek immediate medical help if you notice signs of a severe reaction, such as:

• Difficulty breathing
• Rapid heartbeat
• Chest tightness
• Swelling of lips, tongue, or throat
• Feeling faint

Before Taking

Inform your doctor or nurse if any of the following apply to you:

• You’ve had a stroke or history of blood clots
• You have heart disease or a central line catheter
• You are pregnant, planning pregnancy, or breastfeeding

Haegarda is generally well tolerated but should always be used under medical supervision, especially if you’ve had previous complications with blood-derived medicines.

What to Avoid

There are no specific restrictions on food or drink while using Haegarda. However, always follow your doctor’s guidance regarding:

• Physical activity after injection
• Managing bleeding or bruising at injection sites
• Using any other blood-derived products

Interactions

Tell your doctor if you are taking:

• Hormonal contraceptives (e.g., birth control pills)
• Testosterone or anabolic steroids

These may increase the risk of blood clots, particularly when used with C1 esterase inhibitors.

Always inform your healthcare provider about all medications you take, prescription, over-the-counter, herbal, or vitamin supplements.

Dosage

Haegarda is typically self-administered after training or administered by a carer. It is injected subcutaneously (under the skin) using a syringe or infusion device.

Recommended dose:

• 60 IU per kg of body weight
• Twice weekly (every 3–4 days)

Dosage may vary by age, body weight, and medical need. Always follow your specialist’s guidance and the instructions included in the packaging.

How to Use Haegarda

• Reconstitute the medicine just before use as instructed in your patient leaflet
• Administer by subcutaneous injection into the abdomen or thigh
• Each vial is for single-use only
• Use reconstituted solution immediately or within 8 hours if stored at room temperature
• Do not freeze. Keep Haegarda in its original packaging, away from light

Dispose of used needles and syringes in an approved sharps container, and follow local disposal guidelines.

What Happens If I Miss a Dose?

If you miss a dose, contact your doctor or specialist nurse as soon as possible for advice. It’s important not to skip doses to maintain protection against HAE attacks.

If you are travelling, ensure Haegarda is stored and transported properly and that you carry enough supply.

What Happens If I Overdose?

In case of overdose, seek urgent medical attention or contact the NHS 111 service or the Poison Information Centre.

Frequently Asked Questions (FAQ)

1. Is Haegarda a cure for HAE?
No. Haegarda is used for prevention only. It doesn’t cure the underlying genetic condition, but can significantly reduce the frequency and severity of attacks.

2. Can I travel with Haegarda?
Yes, but keep it refrigerated or at room temperature as advised, and use a cool bag if necessary. Always carry extra supplies when travelling.

3. Can children use Haegarda?
Yes, it is licensed for use in patients aged 6 years and older, with dosage adjusted according to body weight.

4. Can I still have attacks while using Haegarda?
Although Haegarda reduces the likelihood of attacks, some patients may still experience breakthrough episodes. Keep your emergency medication on hand and consult your HAE specialist.

Related Alternatives

• Takhzyro (lanadelumab) – preventive treatment
• Cinryze – another C1 esterase inhibitor
• Firazyr (icatibant) – used for acute attacks
• Berinert – acute HAE treatment
• Orladeyo (berotralstat) – once-daily oral preventive

Your doctor will help determine which treatment best suits your condition and lifestyle.

Further Information

Always keep this and all medicines out of reach of children. Never share your medication with others. Use Haegarda only for the condition prescribed and as directed by your healthcare provider.

Medical Disclaimer:

This content is for informational purposes only and does not replace medical advice. Always consult your GP, pharmacist, or specialist nurse for individual care.