With GLP-1 weight-loss drugs like Wegovy (semaglutide) and Mounjaro (tirzepatide) attracting growing demand, private providers such as SheMed and MedExpress have become go-to options for those seeking prescriptions outside the NHS. As patients weigh cost, safety, and service, a closer look reveals where value lies , notably, SheMed often delivers lower entry prices with structured support, while MedExpress offers a flexible no-subscription model that’s widely used but may cost more over time.
Understanding GLP-1, Semaglutide and Tirzepatide
GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications that mimic a naturally occurring hormone in the body to reduce appetite, slow digestion, and improve blood sugar regulation. Originally developed for type 2 diabetes, they are now widely used off-label or via private prescription for weight loss.
- Semaglutide, the active ingredient in Wegovy, has been shown to deliver weight reductions of up to ~15% when combined with lifestyle changes.
- Tirzepatide, marketed as Mounjaro, is a dual GIP/GLP-1 agonist and has demonstrated even more dramatic weight loss for some, often cited up to ~20%.
- Safety matters: Providers emphasise clinical oversight, gradual dose escalation and monitoring, mirroring MHRA guidance on prescription GLP-1 use.
SheMed’s Edge: Affordable Subscription-Style Care
SheMed is well-known for its subscription-style weight-loss service, targeting long-term users looking for simplicity and consistent support. Key advantages include:
- Low first-month price for lower-dose Wegovy.
- Fixed monthly pricing for higher doses, making budgeting more predictable.
- Bundled clinical care, including support packs and regular monitoring.
This model appeals particularly to those who plan to stay on GLP-1 treatment for many months and want to avoid surprise costs.
MedExpress: Flexible, No-Subscription, But Trade-Offs
MedExpress, by contrast, offers a pay-as-you-go model without long-term subscription commitment. Key features:
- NHS-registered pharmacy .
- Weekly GLP-1 injectables with per-pen pricing.
- Price-match guarantee: MedExpress reportedly matches publicly advertised prices from other pharmacies.
- Risks: according to user reports, there have been delivery delays, and dose shortages (for example, 2.5 mg Mounjaro) have been reported.
Because there’s no bundled service, overall cost over months may be higher than with subscription providers, especially as doses escalate.
Price Comparison: SheMed vs MedExpress
Here’s a breakdown of the published private-market pricing for both providers, based on publicly available data (note: these are typical “programme” or per-pen costs, and may change).
Wegovy (Semaglutide) – Dose Price Comparison
| Dose (weekly) | SheMed Price (per 4 weeks) | MedExpress Price |
| 0.25 mg | first month £79 | £99.99 First Month |
| 0.5 mg | £139 | £119.99 |
| 1.0 mg | £139 | £149.99 |
| 1.7 mg | £159 | £179.99 |
| 2.4 mg | £159 | £199.99 |
Mounjaro (Tirzepatide) – Dose Price Comparison
| Dose (weekly) | SheMed Price (per 4 weeks) | MedExpress Price (approx.) |
| 2.5 mg | £179 | £179.99 |
| 5 mg | £229 | £189.99 |
| 7.5 mg | £279 | £249.99 |
| 10 mg | £279 | £279.99 |
| 12.5 mg | £319 | £299.99 |
| 15 mg | £319 | £309.99 |
Strengths & Trade-offs: SheMed vs MedExpress
Why SheMed may be better for many patients:
- Better for long-term GLP-1 users: Fixed monthly costs help with financial planning across the entire treatment journey.
- Integrated care: Subscription model means more predictable clinical oversight, which can be especially helpful when titrating doses.
Where MedExpress shines:
- No subscription needed: Ideal for those who want to try GLP-1 for a few months without committing long-term.
- Transparent per-pen pricing: Clear cost per pen with no hidden monthly fee.
- Price-match guarantee: Users report being able to match competitor pharmacy fees.
Risks and concerns with MedExpress:
- Dose availability issues (some users report supply problems for specific tirzepatide strengths).
- Prescription changes: There are reports of MedExpress updating policies, for instance limiting prescription continuation after a certain period.
Final Verdict: Which Provider Suits Which Patient?
For patients committed to a long-term GLP-1 weight-loss journey, SheMed offers compelling value through its bundled, fixed-fee model. It’s particularly suited to those who want structured support, dose monitoring and predictable costs.
MedExpress, on the other hand, caters well to those who prefer flexibility, want to try GLP-1 without a subscription, or dislike committing to monthly programmes. However, users must be vigilant about price changes, pen availability and possible policy shifts.
As with any medical treatment , especially powerful prescriptions like semaglutide or tirzepatide , patients should consult a qualified clinician, review the latest pharmacy prices, check for regulatory compliance, and stay alert for dose supply issues.
Learn more or explore a structured programme with SheMed here: https://www.shemed.co.uk/
